Identification of women at high genetic risk of breast cancer through the National Health Service Breast Screening Programme (NHSBSP).
نویسندگان
چکیده
منابع مشابه
Identification of women at high genetic risk of breast cancer through the National Health Service Breast Screening Programme (NHSBSP).
Breast cancer is a multifactorial disease with an inherited predisposition being implicated in around 5% of all cases. Using previous epidemiological data assessing risks for the relatives of women with breast cancer, we have identified 154 women (from a screened population of 35,505) and 289 of their relatives between 50 and 64 years who have more than twice the age related risk of developing ...
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چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولBreast Cancer Screening in High-Risk Women
Women who are at a significantly raised risk of developing breast cancer should be assessed by a medical geneticist to confirm their history, counselled as to appropriate management and offered breast screening. Currently mammography with magnetic resonance imaging is considered the optimal method of early detection of breast cancer in these women. While there is no evidence of mortality benefi...
متن کاملRisk of breast cancer in women who attend the NHS breast screening programme: cohort study.
Not all women invited to participate in the NHS breast screening programme will do so; those who do not may differ in their risk of breast cancer from those who do. This “self selection” for screening can result in women at either high or low risk being overrepresented in those screened. A screening programme in which those who attend have a high risk of breast cancer is likely to detect more c...
متن کاملTolerability of breast ductal lavage in women from families at high genetic risk of breast cancer
BACKGROUND Ductal lavage (DL) has been proposed as a minimally-invasive, well-tolerated tool for obtaining breast epithelial cells for cytological evaluation of breast cancer risk. We report DL tolerability in BRCA1/2 mutation-positive and -negative women from an IRB-approved research study. METHODS 165 BRCA1/2 mutation-positive, 26 mutation-negative and 3 mutation unknown women underwent mam...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1995
ISSN: 1468-6244
DOI: 10.1136/jmg.32.11.862